Jarisch-Herxheimer Reaction in Lyme Disease
In 7-30% of Lyme disease cases, antibiotic treatment triggers the Jarisch-Herxheimer reaction. This entails a worsening of symptoms over a period ranging from several days to a few weeks 1.
This response occurs due to the rapid destruction of a large number of microorganisms, leading to the release of non-endotoxin pyrogens and lipoproteins into the bloodstream 2. These toxins stimulate a robust pro-inflammatory response.
Research indicates that the severity of the reaction correlates with the bacterial load of the infected individual 3. Also referred to as the "healing crisis," the Jarisch-Herxheimer reaction serves as compelling evidence of the effectiveness of the antibiotic regimen or therapy being administered.
Given this phenomenon, our clinic places significant emphasis on detoxification therapies aimed at improving liver and kidney function.
Bibliografie
2. Nykytyuk, Svitlana, et al. "The Jarisch-Herxheimer reaction associated with doxycycline in a patient with Lyme arthritis." Reumatologia 58.5 (2020): 335.
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